FETAL BIOMETRY OF SKELETAL DYSPLASIAS - A MULTICENTRIC STUDY

Twenty-three diagnostic centers worldwide contributed 127 cases of 17 skeletal dysplasias. Discriminant analysis showed that the femur lengt h was the best biometric parameter to distinguish among the five most common disorders in this series (thanatophoric dysplasia, osteogenesis imperfecta type II, achondrogenesis, achonhroplasia and hypochondropl asia). Fifty-four percent of fetuses with femur length below 30% of th e mean for gestational age had achondrogenesis. Seventy-eight percent of measurements between 40 and 60% of the mean for gestational age rep resented either thanatophoric dysplasia or osteogenesis imperfecta typ e II. Fetuses who had over 80% of the mean for gestational age had pre dominantly hypochondroplasia, achondroplasia, and osteogenesis imperfe cta type III.