THE INTRATHYMIC TARGET-CELL FOR THE THYMOTOXIC ACTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

Authors
DEHEER C DEWAAL EJ SCHUURMAN HJ VOS JG VANLOVEREN H
Citation
C. Deheer et al., THE INTRATHYMIC TARGET-CELL FOR THE THYMOTOXIC ACTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, Experimental and clinical immunogenetics, 11(2-3), 1994, pp. 86-93
Citations number
29
Categorie Soggetti
Genetics & Heredity",Immunology,Biology
Journal title
Experimental and clinical immunogenetics → ACNP
ISSN journal
02549670
Volume
11
Issue
2-3
Year of publication
1994
Pages
86 - 93
Database
ISI
SICI code
0254-9670(1994)11:2-3<86:TITFTT>2.0.ZU;2-E
Abstract
Sublethal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produ ces thymic atrophy and thymic lymphodepletion in all species investiga ted. Lymphodepletion is first seen in the cortex of the thymus, but al so occurs in the medulla at later time points. This article surveys in vivo and in vitro studies on TCDD-induced thymus toxicity. It is conc luded that the first intrathymic target cell for the action of TCDD is the cortical epithelial cell.