MODULATION OF GROWTH-FACTOR EXPRESSION BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environment al contaminant, which causes a variety of toxic effects including alte rations in cell growth and differentiation. In the last years it becam e increasingly evident that growth factors and their corresponding rec eptors are involved in toxic responses of this compound. The interfere nce of TCDD with growth factor expression has been studied in several in vitro and in vivo systems. Here, we give a short summary of the pub lished data about interactions between TCDD and growth factors.