SERUM CONCENTRATION OF PROCOLLAGEN TYPE-I CARBOXYTERMINAL PROPEPTIDE IN LOCALIZED SCLERODERMA

Background and Design: Recently, we reported that the serum procollage n type I carboxyterminal propeptide (P1CP) level of patients with syst emic sclerosis was elevated and correlated with disease severity. In t his study, the serum level of P1CP was measured using the enzyme-linke d immunosorbent assay in 39 patients with localized scleroderma and in 30 control subjects. Results: The mean P1CP level, in the patients wa s significantly higher than that in the normal control subjects. In 30 % of the patients with localized scleroderma, the serum P1CP level was considered to be elevated (>305 ng/mL; ie, 2 SDs above the mean contr ol value). The mean serum P1CP level in the patients with generalized morphea was significantly higher than in the patients with morphea or linear scleroderma. In addition, the serum P1CP level in the patients with localized scleroderma was correlated with the number of sclerotic lesions, and it was negatively correlated with the duration of the di sease. Anti-single-stranded DNA antibody and antihistone antibody were detected significantly more frequently in the patients with elevated P1CP than in the patients with normal P1CP. Conclusion: These findings suggest that the serum P1CP-level is a useful indicator of disease se verity in patients with localized scleroderma, as it has been found to be in those with systemic sclerosis.