MONTE-CARLO SIMULATION OF LIGAND-RECEPTOR INTERACTIONS ON A CELL-SURFACE

In this paper we develop a compartmentalized, discrete simulation mode l for investigating the spatial distribution and dynamic properties of receptor crosslinking on the surface of a cell. Results generated by the model are compared with some of the major results of existing anal ytical models, and differences are discussed in relation to difference s in the model assumptions. Finally, the model is used to evaluate the dynamic effects of a time-varying non-homogeneous ligand concentratio n.