ABNORMAL CYTOSKELETAL PATHOLOGY PECULIAR TO CORTICOBASAL DEGENERATIONIS DIFFERENT FROM THAT OF ALZHEIMERS-DISEASE OR PROGRESSIVE SUPRANUCLEAR PALSY

An autopsy case of clinically diagnosed ''corticobasal degeneration (C BD)'' was investigated. In addition to status spongiosus and neuronal achormasia around the central sulcus, cortical pyramidal neurons and t hread-like structures were densely stained by Gallyas stain and tan im munohistochemistry, but apparent fibrillary structures like Alzheimer' s disease neurofibrillary tangle were absent. Bodian, methenamine-Bodi an, Congo red, thioflavin S, or Bielshowsky stains failed to visualize these structures. They were not stained by immunohistochemical stain with anti-ubiquitin antibody. The widespread cytoskeletal pathology, w hich is distinct from that in Alzheimer's disease or progressive supra nuclear palsy, is suggestive of CBD.