ANALYSIS OF AUDITORY BRAIN-STEM RESPONSE WITH LIDOCAINE INJECTION INTO THE CEREBROSPINAL, FLUID IN RATS

Authors
YAMADA K TSUZUKU T KAGA K UNO A
Citation
K. Yamada et al., ANALYSIS OF AUDITORY BRAIN-STEM RESPONSE WITH LIDOCAINE INJECTION INTO THE CEREBROSPINAL, FLUID IN RATS, The Annals of otology, rhinology & laryngology, 103(10), 1994, pp. 796-800
Citations number
12
Categorie Soggetti
Otorhinolaryngology
Journal title
The Annals of otology, rhinology & laryngology → ACNP
ISSN journal
00034894
Volume
103
Issue
10
Year of publication
1994
Pages
796 - 800
Database
ISI
SICI code
0003-4894(1994)103:10<796:AOABRW>2.0.ZU;2-L
Abstract
Auditory brain stem response (ABR) was recorded in 10 rats with total spinal anesthesia induced by injection of 2% lidocaine hydrochloride i nto the subarachnoid space through the skull. The ABR disappeared imme diately (within 4 minutes) after the injection of 13.3 to 40.0 mg/kg l idocaine. The disappearance started with the later waves of the ABR. A fter cessation of the injection, the ABR reappeared and recovered prog ressively from wave I to wave IV. The effect of lidocaine on the ABR w as reversible and extended in the acoustic nerve to the midbrain.