DIURESIS AND NATRIURESIS IN NON-SEIZING AND IN KINDLED RATS FROM A GENETICALLY AUDIOGENIC SUSCEPTIBLE STRAIN

AUDIOGENIC seizures are evoked by acoustic stimulation in susceptible (S) but not in resistant (R) rats. Repeated audiogenic seizures recrui t limbic areas, a model called audiogenic kindling. In order to evalua te excretory patterns (urinary volume, Na+ and K+ excretion), S and R animals were non-stimulated, submitted to one (acute) or 10 (kindled) stimulations or to two aqueous overloads (5% b.w). Non-stimulated S an imals displayed a significant increase (p < 0.05) in Na+ excretion at 60, 80, 100 and 120 min. Acutely stimulated S animals showed greater n atriuresis than non-stimulated animals at 80, 60, 80 and 100 min. Kind led S animals displayed the greatest natriuresis (p < 0.005) at 40, 60 , 80, 100 and 120 min and the highest diuretic response (p < 0.05) at 40, 60 and 80 min. Abnormalities of the endogenous hydroelectrolytic p rofile of non-stimulated S animals and their overt expression in kindl ed rats may be related to alterations in neuroendocrine systems regula ting hydroelectrolytic balance, in addition to the long-lasting effect s of kindled seizures.