APO-E-ALLELE FREQUENCIES IN ALZHEIMERS-DISEASE, LEWY BODY DEMENTIA, ALZHEIMERS-DISEASE WITH CEREBROVASCULAR-DISEASE AND VASCULAR DEMENTIA

Citation
C. Betard et al., APO-E-ALLELE FREQUENCIES IN ALZHEIMERS-DISEASE, LEWY BODY DEMENTIA, ALZHEIMERS-DISEASE WITH CEREBROVASCULAR-DISEASE AND VASCULAR DEMENTIA, NeuroReport, 5(15), 1994, pp. 1893-1896
Citations number
28
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
09594965
Volume
5
Issue
15
Year of publication
1994
Pages
1893 - 1896
Database
ISI
SICI code
0959-4965(1994)5:15<1893:AFIALB>2.0.ZU;2-E
Abstract
APOLIPOPROTEIN (APo E) was genotyped using a fluorescent PCR-RFLP assa y in 187 patients with a probable or possible clinical diagnosis of sp oradic Alzheimer's disease (AD) and in 166 autopsied patients with dem entia (21 presenile AD, 70 senile AD, 18 Lewy body dementia (LBD), 38 AD with cerebrovascular disease (AD-CVD), 19 vascular dementia). The r elative epsilon 4 allele frequency was 0.472 in LBD, 0.513 in AD-CVD, 0.405 in presenile AD, 0.364 in senile AD, and 0.079 in vascular demen tia. The relative epsilon 2 allele frequency was 0.211 in vascular dem entia, 0.083 in LBD, 0.047 in presenile AD, 0.100 in senile AD and 0.0 39 in AD with CVD. We infer that apo E is a major risk factor for stru ctural phenotypes of dementia involving AD, alone or in conjunction wi th another pathology. In addition, the epsilon 2 allele is likely to r epresent a risk factor for vascular morbidity, as the relative epsilon 2 allele frequency was 0.211 in patients with vascular dementia compa red with 0.144 in elderly controls.