ALPHA-1-ADRENOCEPTOR AND ALPHA-2-ADRENOCEPTOR SUBSENSITIVITY IN SIBLINGS OF OPIOID ADDICTS WITH PERSONALITY-DISORDERS AND DEPRESSION

Authors
GERRA G CACCAVARI R MARCATO A ZAIMOVIC A AVANZINI P MONICA C MUTTI A FONTANESI B DELSIGNORE R BRAMBILLA F
Citation
G. Gerra et al., ALPHA-1-ADRENOCEPTOR AND ALPHA-2-ADRENOCEPTOR SUBSENSITIVITY IN SIBLINGS OF OPIOID ADDICTS WITH PERSONALITY-DISORDERS AND DEPRESSION, Acta psychiatrica Scandinavica, 90(4), 1994, pp. 269-273
Citations number
31
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Acta psychiatrica Scandinavica → ACNP
ISSN journal
0001690X
Volume
90
Issue
4
Year of publication
1994
Pages
269 - 273
Database
ISI
SICI code
0001-690X(1994)90:4<269:AAASIS>2.0.ZU;2-R
Abstract
Noradrenergic receptor sensitivity of 16 healthy male siblings of hero in addicts and of 8 age and sex-matched controls was examined by admin istering a clonidine stimulation test and by measuring the resulting g rowth hormone (GH) (alpha-2-adrenoceptors) and beta-endorphin (beta-en dorphin) (alpha-l-adrenoceptors) responses. Siblings were divided into two groups: A = siblings of heroin addicts with personality disorders and high aggressivity and B = siblings of heroin addicts without ment al disorders. The GH and beta-endorphin responses to clonidine were bl unted in group A subjects compared with controls and normal in group B .