UPTAKE OF TC-99M-EXAMETAZIME SHOWN BY SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY IN OBSESSIVE-COMPULSIVE DISORDER COMPARED WITH MAJOR DEPRESSION AND NORMAL CONTROLS

Citation
Y. Edmonstone et al., UPTAKE OF TC-99M-EXAMETAZIME SHOWN BY SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY IN OBSESSIVE-COMPULSIVE DISORDER COMPARED WITH MAJOR DEPRESSION AND NORMAL CONTROLS, Acta psychiatrica Scandinavica, 90(4), 1994, pp. 298-303
Citations number
43
Categorie Soggetti
Psychiatry,Psychiatry
ISSN journal
0001690X
Volume
90
Issue
4
Year of publication
1994
Pages
298 - 303
Database
ISI
SICI code
0001-690X(1994)90:4<298:UOTSBS>2.0.ZU;2-J
Abstract
Twelve patients with obsessive-compulsive disorder (OCD) were investig ated at rest using single photon emission computerized tomography with Tc-99m-exametazime. The uptake of Tc-99m-exametazime was expressed re lative to calcarine/occipital cortex. Patients were matched for drug t reatment with 12 patients with a major depressive episode and the pati ent groups were compared with a control group. Significant bilateral d ecreases in tracer uptake were confined to basal ganglia in the OCD gr oup. There was a paradoxical positive correlation between anxiety rati ngs and tracer uptake to basal ganglia in the OCD group. The findings confirm that the functional topography of OCD implicates altered funct ion in the basal ganglia.