IMMUNOHISTOCHEMICAL STUDY ON THE INFECTION OF HERPES-SIMPLEX VIRUS, HUMAN CYTOMEGALOVIRUS, AND EPSTEIN-BARR-VIRUS IN SECONDARY DIFFUSE INTERSTITIAL PNEUMONIC
Y. Oda et al., IMMUNOHISTOCHEMICAL STUDY ON THE INFECTION OF HERPES-SIMPLEX VIRUS, HUMAN CYTOMEGALOVIRUS, AND EPSTEIN-BARR-VIRUS IN SECONDARY DIFFUSE INTERSTITIAL PNEUMONIC, Human pathology, 25(10), 1994, pp. 1057-1062
We examined the infection of herpes simplex virus (HSV), human cytomeg
alovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with
secondary diffuse interstitial pneumonia (SDIP) by immunohistochemist
ry and compared our findings with those in 46 individuals without lung
complications. There was no significant difference in positivity of H
SV infection between SDIP cases (28 of 61; 45.9%) and the controls (24
of 46; 52.2%). However, HSV was more extensively distributed in the l
ungs of seven SDIP eases than in those of controls and proliferated to
form inclusion bodies in host cells of 11 SDIP cases. Twenty-two (36.
1%) and 19 (31.1%) SDIP cases were positive for HCMV and EBV, respecti
vely, whereas all the 46 controls were negative for both viruses. Eigh
teen of 22 HCMV-positive cases contained classical inclusion bodies in
host cells. Epstein-Barr virus was detected extensively in the lungs
of seven SDIP patients, but no viral inclusion bodies were observed in
host cells. These findings indicate that the herpes viruses replicate
excessively in a considerable number of SDIP cases, but classical inc
lusion bodies are not always associated with viral infection in the lu
ngs. Major infected cells of these viruses were alveolar lining pneumo
cytes and intra-alveolar cells. Herpes simplex virus and EBV were dete
cted in leukocytes as well as in pneumocytes. In addition, compared wi
th HCMV and HSV, EBV frequently multiplied in bronchial or bronchiolar
epithelial cells. Preferential host cells for these types of herpes v
irus were somewhat different from one another. Copyright (C) 1994 by W
.B. Saunders Company