A BIOMIMETIC SYNTHESIS OF A NEW SKELETAL GELSEMIUM ALKALOID 11-METHOXY-19(R)-HYDROXYGELSELEGINE

Authors
TAKAYAMA H KITAJIMA M SAKAI S
Citation
H. Takayama et al., A BIOMIMETIC SYNTHESIS OF A NEW SKELETAL GELSEMIUM ALKALOID 11-METHOXY-19(R)-HYDROXYGELSELEGINE, Tetrahedron, 50(41), 1994, pp. 11813-11820
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
41
Year of publication
1994
Pages
11813 - 11820
Database
ISI
SICI code
0040-4020(1994)50:41<11813:ABSOAN>2.0.ZU;2-5
Abstract
Based on a suggested biogenetic sequence, a sarpagine-type indole alka loid, gardnerine (2), was stereoselectively converted to a new skeleta l type Gelsemium alkaloid, 11-methoxy-19(R)-hydroxygelselegine (1), vi a biogenetically hypothetical aziridine intermediate (17).