TREATMENT OF LINEAR LOCALIZED SCLERODERMA WITH THE ANTIALLERGIC DRUG,TRANILAST

Authors
TANIGUCHI S YORIFUJI T HAMADA T
Citation
S. Taniguchi et al., TREATMENT OF LINEAR LOCALIZED SCLERODERMA WITH THE ANTIALLERGIC DRUG,TRANILAST, Clinical and experimental dermatology, 19(5), 1994, pp. 391-393
Citations number
11
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Clinical and experimental dermatology → ACNP
ISSN journal
03076938
Volume
19
Issue
5
Year of publication
1994
Pages
391 - 393
Database
ISI
SICI code
0307-6938(1994)19:5<391:TOLLSW>2.0.ZU;2-T
Abstract
A 14-year-old boy with linear localized scleroderma had a dramatic imp rovement in contractures after treatment with N-(3',4'-dimethoxycinnam oyl) anthranilic acid (tranilast, Rizaben(R)). The observation that th is antiallergic drug was effective in localized scleroderma lends furt her support to the concept that mast cells play a role in increased co llagen synthesis in this disease.