A 73-year-old man had been treated for a sore, red, left eye for 4 mon
ths before a clinical diagnosis of squamous cell carcinoma of the limb
us was made. This diagnosis was confirmed on examination of a biopsy s
pecimen, but after an initial surgical attempt to fully excise the tum
or, there was clinical evidence of intraocular spread. An extensive co
rneoscleral resection and iridocyclectomy appeared to completely excis
e the tumor, as indicated by frozen section review. However, 1 year la
ter, the patient re-presented with obvious residual squamous cell carc
inoma of the iris and trabecular meshwork, well away from the original
tumor site. Subsequent exenteration has resulted in a tumor-free pati
ent for 1 year. Apparent surgical clearance of an extensive squamous c
ell carcinoma does not ensure total intraocular clearance of residual
tumor, which may be remote from the original tumor site.