PATHOPHYSIOLOGY OF RENAL-FAILURE IN RENOVASCULAR DISEASE

Recent attention has focused on renovascular compromise as a cause of chronic renal failure. The sequence by which kidneys functioning near the limits of ''critical perfusion pressures'' develop parenchymal inj ury is not well understood. We studied poststenotic renal pressures, g lomerular volume, and renal function in conscious rats using an aortic coarct model during antihypertensive therapy with sodium restriction and angiotensin-converting enzyme inhibition over 4 weeks. These were compared with acute reduction of renal pressures using aortic ligation . Both models reduced poststenotic pressures to 50 to 60 mm Hg. Total aortic ligation produced tubular necrosis and glomerular collapse with 40-fold elevated urinary N-acetyl-glucosaminidase excretion. In contr ast, angiotensin-converting enzyme inhibition reduced renal blood flow by 30% without evident disruption in tubular function, reflected by l ow fractional excretion of sodium levels and normal excretion of N-ace tyt-glucosaminidase. The glomerular filtration rate and filtration fra ction were reduced. These results indicate that gradual reduction of r enal perfusion pressure produces functional and morphologic consequenc es different from those observed with acute ischemic injury. Mechanism s by which chronic renal perfusion deficits produce tissue injury are reviewed and may include disruption of vascular regulation, energy sto rage molecules, cellular ion gradients, free radical generation, and d isruption of cytoskeletal configuration and repair mechanisms. Further study of the pathways of chronic renal parenchymal injury beyond arte rial stenosis is essential to achieve rational intervention and revasc ularization in humans. (C) 1994 by the National Kidney Foundation, Inc .