GASTRIC-EMPTYING OF INGESTED SOLUTIONS IN MAN - EFFECT OF BEVERAGE GLUCOSE-CONCENTRATION

The purpose of this study was to compare the rate of gastric emptying of 20 g.l(-1) (2G), 40 g.l(-1) (4G), and 60 g.l(-1) (6G) glucose solut ions with that of water (W). On separate occasions in randomized order , a 600-ml test solution was instilled into the stomach of each of six healthy male volunteers. Gastric emptying was measured at 10-min inte rvals for 1 h by a double sampling gastric aspiration method that allo wed the Volume of test drink and of the gastric secretion present in t he stomach to be measured at each time point. All solutions emptied ra pidly and followed an exponential emptying pattern. The 20 g.l(-1) glu cose solution was emptied at the same rate as water. After the first 1 0 min of rapid emptying, 4G and 6G were emptied slower (P < 0.05) than water. 6G delivered more (P < 0.05) glucose to the small intestine th an 4G, and 4G delivered more glucose than 2G. The results indicate tha t a 20 g.l(-1) glucose solution has no effect on gastric emptying comp ared with water, but that after the first 10 min of rapid emptying, gl ucose solutions at a concentration of 40 g.l(-1) or more delay gastric emptying.