P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN THE DORSOLATERAL PREFRONTAL CORTEX OF SCHIZOPHRENICS WITH A VOLUME SELECTIVE TECHNIQUE - PRELIMINARY FINDINGS

Pettegrew, et al (Arch Gen Psychiatry 48:563-568, 1991) were the first to determine abnormalities concerning phospholipids and high energy m etabolites in the dorsolateral prefrontal cortex of drug-naive schizop hrenics with P-31 magnetic resonance spectroscopy (MRS). Other investi gations could not replicate these findings. We included in our study 1 3 schizophrenic inpatients and 14 age-matched controls, Whereas Petteg rew et al found increased levels of phosphodiesters and decreased leve ls of phosphomonoesters we measured decreased levels of phosphodiester s in the schizophrenics as compared to controls. One possible explanat ion for the contradictory findings of the both trials might be the dif ferent localization techniques used. (C) 1997 Society of Biological Ps ychiatry.