Cm. Allen et al., NECROSIS IN BENIGN SALIVARY-GLAND NEOPLASMS - NOT NECESSARILY A SIGN OF MALIGNANT TRANSFORMATION, Oral surgery, oral medicine, oral pathology, 78(4), 1994, pp. 455-461
Citations number
13
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Necrosis that occurs in a salivary gland neoplasm is usually considere
d to be an ominous sign, suggesting malignant transformation, particul
arly in lesions that have had no prior manipulation such as fine-needl
e aspiration. We describe five pleomorphic adenomas and two canalicula
r adenomas of salivary gland origin that exhibited necrosis, yet were
otherwise benign. All lesions displayed a distinctive histopathologic
pattern characterized by a narrow rim of viable tumor tissue at the pe
riphery of the neoplasm combined with a diffuse central region that de
monstrated apparent ischemic necrosis. No invasion of adjacent normal
tissue was identified, and no recurrence or metastasis has been seen w
ith these lesions. Caution should be exercised in the evaluation of sa
livary gland neoplasms with central necrosis to avoid misdiagnosis of
all such lesion as malignant.