Km. Hargreaves et al., PHARMACOLOGY OF PERIPHERAL NEUROPEPTIDE AND INFLAMMATORY MEDIATOR RELEASE, Oral surgery, oral medicine, oral pathology, 78(4), 1994, pp. 503-510
Citations number
39
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Research conducted in the last 10 years has increased our knowledge on
pain mechanisms substantially. Although many local tissue mediators,
including neuropeptides, are known to exert pro-inflammatory effects,
comparatively little is known about the actual tissue levels of these
inflammatory mediators and their pharmacologic regulation. This articl
e describes two new methods, clinical microdialysis and superfusion of
dental pulp, which provide data on the pharmacology of peripheral neu
ropeptide and inflammatory mediator release. Collectively, these metho
ds provide a biochemically based approach toward determining the mecha
nisms and management of orofacial pain.