AN IN-SITU HYBRIDIZATION STUDY ON INTERLEUKIN-1-BETA MESSENGER-RNA INDUCED BY TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT-BRAIN

Authors
YABUUCHI K MINAMI M KATSUMATA S YAMAZAKI A SATOH M
Citation
K. Yabuuchi et al., AN IN-SITU HYBRIDIZATION STUDY ON INTERLEUKIN-1-BETA MESSENGER-RNA INDUCED BY TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT-BRAIN, Molecular brain research, 26(1-2), 1994, pp. 135-142
Citations number
32
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
26
Issue
1-2
Year of publication
1994
Pages
135 - 142
Database
ISI
SICI code
0169-328X(1994)26:1-2<135:AIHSOI>2.0.ZU;2-C
Abstract
Expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain aft er transient forebrain ischemia was investigated by in situ hybridizat ion histochemistry. Thirty min after the start of recirculation, IL-1 beta mRNA was induced in the several brain regions, including the olfa ctory bulb, cerebral cortex, hippocampus, striatum and thalamus where neuronal degeneration was reported to be observed after transient fore brain ischemia. The hybridization signals were observed both on the gl ial cells and around the vascular walls.