SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY (SPECT) MEASURES OF BRAIN-FUNCTION IN SCHIZOPHRENIA

Authors
GORDON E BARRY RJ ANDERSON J FAWDRY R YONG C GRUNEWALD S MEARES RA
Citation
E. Gordon et al., SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY (SPECT) MEASURES OF BRAIN-FUNCTION IN SCHIZOPHRENIA, Australian and New Zealand Journal of Psychiatry, 28(3), 1994, pp. 446-452
Citations number
63
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Australian and New Zealand Journal of Psychiatry → ACNP
ISSN journal
00048674
Volume
28
Issue
3
Year of publication
1994
Pages
446 - 452
Database
ISI
SICI code
0004-8674(1994)28:3<446:SEC(MO>2.0.ZU;2-X
Abstract
This study explores SPECT measured in schizophrenic patients at rest. Left temporal lobe activity was found to be decreased with increasing positive symptoms' scores scores. Medicated patients showed a reversal of this pattern underlying this positive symptom effect. Patients wit h a recent history of auditory hallucinations showed an atypical right temporal lobe dominance, which occurred independently of medication s tatus. These preliminary data are suggestive of the potential utility of SPECT to elucidate symptom/medication/brain activity interrelations hips in schizophrenia.