Purpose: The influence of various preoperative, intraoperative, and po
stoperative factors on retinal reattachment after scleral buckling was
examined. Methods: A study of 601 eyes of 577 consecutive patients wh
o underwent conventional scleral buckling procedures was conducted. Mu
ltiple logistic regression analysis was used to determine the independ
ent influence of each variable on anatomic failure. Results: Anatomic
reattachment of the retina was achieved in 86% of eyes after a single
procedure, and in 90% of eyes after a second surgical procedure, with
a mean follow-up period of 5.27 months (range, 2-29 months). Factors p
redictive of poor anatomic success (P < 0.05) included preoperative ch
oroidal detachment and significant vitreous opacification; circumferen
tial buckle extent of more than two quadrants and intravitreal injecti
on of air or fluid intraoperatively; and postoperative occurrence of s
terile vitritis. Conclusion: Breakdown of the blood-retinal barrier le
ading to cellular migration and proliferation is considered to be pred
ictive of anatomic failure after scleral buckling procedures.