EXPERIMENTAL SACCULAR ANEURYSMS .1. REVIEW OF SURGICALLY-CONSTRUCTED MODELS AND THEIR LABORATORY APPLICATIONS

Experimental models of intracranial saccular aneurysms are a useful co ntribution to our basic understanding of these lesions. Currently, the commonest in use are those constructed surgically in laboratory anima ls. We review the numerous surgical techniques available since the 195 0s, and the research applications and uses of experimental aneurysms. Further development and use of such models is greatly encouraged in fu ture pathophysiological, hemodynamic, and therapeutic investigations o f intracranial saccular aneurysms.