A FACILE METHOD FOR THE PREPARATION OF 4-HYDROXY-DELTA(2)-ISOXAZOLINES VIA A CYCLOADDITION OXIDATION PROCEDURE EMPLOYING NITRILE OXIDES ANDVINYLBORONIC ESTERS/

Authors
WALLACE RH LIU JC
Citation
Rh. Wallace et Jc. Liu, A FACILE METHOD FOR THE PREPARATION OF 4-HYDROXY-DELTA(2)-ISOXAZOLINES VIA A CYCLOADDITION OXIDATION PROCEDURE EMPLOYING NITRILE OXIDES ANDVINYLBORONIC ESTERS/, Tetrahedron letters, 35(41), 1994, pp. 7493-7496
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
41
Year of publication
1994
Pages
7493 - 7496
Database
ISI
SICI code
0040-4039(1994)35:41<7493:AFMFTP>2.0.ZU;2-B
Abstract
The 1,3-dipolar cycloaddition of aromatic nitrile oxides with trans-1, 2-disubstituted vinylboronic esters affords the 4-boronic ester substi tuted Delta(2)-isoxazoline as the major regioisomer. If the reaction m ixture is treated with t-BuOOH the corresponding 4-hydroxy-Delta(2)-is oxazolines are obtained in good yield.