AN EFFICIENT SYNTHESIS OF A CHIRAL CARBOCYCLIC 2'-DEOXYRIBONUCLEOSIDESYNTHON BY DIRECTED REDUCTION

Authors
BORTHWICK AD CRAME AJ EXALL AM WEINGARTEN GG
Citation
Ad. Borthwick et al., AN EFFICIENT SYNTHESIS OF A CHIRAL CARBOCYCLIC 2'-DEOXYRIBONUCLEOSIDESYNTHON BY DIRECTED REDUCTION, Tetrahedron letters, 35(41), 1994, pp. 7677-7680
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
41
Year of publication
1994
Pages
7677 - 7680
Database
ISI
SICI code
0040-4039(1994)35:41<7677:AESOAC>2.0.ZU;2-2
Abstract
Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ke tone 12 with NaBH(OAc)(3) gave stereoselectively in high yield the 1,4 diol 10, a key intermediate required in our synthesis of chiral carbo cyclic 2'-deoxyribonucleosides.