HISTOPATHOLOGICAL STUDY OF A NEWLY DEVELOPED ROOT-CANAL SEALER CONTAINING TETRACALCIUM-DICALCIUM PHOSPHATES AND 1.0-PERCENT CHONDROITIN SULFATE

We studied the possibility of the clinical use of a calcium phosphate- type newly developed sealer composed of tetracalcium phosphate, dicalc ium phosphate dihydrate, and a modified McIlvain's buffer solution (TD M), Another sealer using the buffer solution, to which 2.5% chondroiti n sulfate was added to promote wound healing (TDM-S), was also studied , TDM and TDM-S were histopathologically compared with another type of calcium phosphate sealer (ARS), which is commercially available in Ja pan, in the dorsal subcutaneous tissue and in the periapical tissue of rats, TDM and TDM-S caused no inflammatory reactions in the subcutane ous tissue, The periapical tissue reacted mildly to them, ARS caused s evere inflammatory reactions in both the subcutaneous and the periapic al tissue. These results indicate that TDM-S has excellent histocompat ibility and potential as a root canal sealer.