D. Vonheimburg et al., FREE TRANSPLANTATION OF FAT AUTOGRAFTS EXPANDED BY TISSUE EXPANDERS IN RATS, British Journal of Plastic Surgery, 47(7), 1994, pp. 470-476
Inguinal fat pads of 28 rats were expanded by tissue expanders for 10
days and transplanted to the back of the same animal. The non-expanded
contralateral inguinal fat pads were also transplanted and served as
controls. Histology showed that adipocytes lose their lipid droplets u
nder mechanical pressure; the expanded adipocytes have an elongated co
ntour with a central nucleus. By the end of the expansion period, the
thickness of the fat pads had decreased by 53%. One week after transpl
antation, expanded fat grafts had regained their previous volume with
little sign of necrosis. Among normal adipocytes numerous smaller cell
s, containing multiple vacuoles, were seen. In contrast, about 25% of
the substance of the non-expanded control fat graft consisted of necro
tic oil cysts. These findings indicate that pre-expanded fat grafts su
rvive better.