SYSTEMIC INFECTION WITH HERPES BOVIS VIRUS-2 EVOKES A BIPHASIC IMMUNE-RESPONSE IN THE MOUSE

We evaluated the effects of systemic infection by Herpes bovis virus 2 (HBV-2) on a murine experimental system. We provide evidence that suc h infection is lethal for the immunocompromised but not for the immuno competent mouse in which a biphasic immune response is elicited. In pa rticular, 1 day post-infection, we observed a rapid transient depressi on induced by the virus, as documented by a decrease in peripheral leu kocyte counts, mitogenic spleen cell response and resistance to a seco ndary microbial challenge. Later: HBV-2 infection boosted cytokine sec retion and enhanced antimicrobial and antitumoral activities by the sp lenic district. In conclusion, our experimental model discloses some i mmunological aspects underlying the complex host-virus interaction.