NETILMICIN INFLUENCES SIDEROPHORES PRODUCTION AND IRON RECEPTOR EXPRESSION IN ESCHERICHIA-COLI

Authors
MIGNINI F BALDUCCI E COVELLI I
Citation
F. Mignini et al., NETILMICIN INFLUENCES SIDEROPHORES PRODUCTION AND IRON RECEPTOR EXPRESSION IN ESCHERICHIA-COLI, The New microbiologica, 17(4), 1994, pp. 337-340
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
17
Issue
4
Year of publication
1994
Pages
337 - 340
Database
ISI
SICI code
1121-7138(1994)17:4<337:NISPAI>2.0.ZU;2-O
Abstract
This study investigated the effect of subinhibitory concentrations of netilmicin on the phenolate (enterochelin), hydroxamate (aerobactin) a nd total siderophores production and on the 81-kDa and 74-kDa receptor s expression in Escherichia coli. Netilmicin at 1/40 MIC reduces total siderophores by 40%; the cathecols by 50% and the hydroxamate by 80%. Concomitant with siderophores reduction, the antibiotic induces the u pregulation of the 81-kDa protein receptor. Both effects reduce the ab ility of the bacterium to survive in the host.