Ca. Mathis et al., SYNTHESIS OF I-123 AND I-125 LABELED 5-IODO-6-NITROQUIPAZINE, Journal of labelled compounds & radiopharmaceuticals, 34(10), 1994, pp. 905-913
The syntheses of the potent and selective serotonin reuptake complex r
adioligands [I-123]- and [I-125]5-iodo-6-nitroquipazine (5-iodo-6-nitr
o-2-piperazinylquinoline) are reported. A seven step synthetic sequenc
e provided the BOC-protected 5-tributyltin-6-nitroquipazine precursor
for radioiodination. End of synthesis radioiodination yields of simila
r to 40% for I-123 and similar to 60% for I-125 were achieved resultin
g in labelled products with high specific activities (>4000 and >2000
Ci/mmol, respectively) and radiochemical purities (>98%).