Sa. Stoneelander et al., A SINGLE-MODE MICROWAVE CAVITY FOR REDUCING RADIOLABELING REACTION-TIMES, DEMONSTRATED BY ALKYLATIONS WITH [C-11] ALKYL-HALIDES, Journal of labelled compounds & radiopharmaceuticals, 34(10), 1994, pp. 949-960
A single-mode microwave cavity was constructed for microscale reaction
s with consideration taken to the space limitations typical for shield
ed working spaces used with positron emitting radionuclides. The effec
t of the microwave field in this cavity on typical reaction media is d
emonstrated. Reaction times for radiolabelling neuroreceptor ligands w
ith [C-11]methyl iodide and [2-C-11]isopropyl iodide were shown to be
considerably seduced compared with the times reported in the literatur
e for the corresponding thermal procedures.