A SINGLE-MODE MICROWAVE CAVITY FOR REDUCING RADIOLABELING REACTION-TIMES, DEMONSTRATED BY ALKYLATIONS WITH [C-11] ALKYL-HALIDES

A single-mode microwave cavity was constructed for microscale reaction s with consideration taken to the space limitations typical for shield ed working spaces used with positron emitting radionuclides. The effec t of the microwave field in this cavity on typical reaction media is d emonstrated. Reaction times for radiolabelling neuroreceptor ligands w ith [C-11]methyl iodide and [2-C-11]isopropyl iodide were shown to be considerably seduced compared with the times reported in the literatur e for the corresponding thermal procedures.