AGENESIS OF THE CORPUS-CALLOSUM IN A MOTHER AND SON

Most reported familial cases of agenesis of the corpus callosum have f ollowed either an autosomal recessive or an X-linked recessive pattern of inheritance. To the best of our knowledge, there is only one previ ous report of a family showing clear-cut autosomal dominant inheritanc e. We present the second such family, among whom a mother and her son had moderately severe coordination problems and low-normal intelligenc e. We suggest that agenesis of the corpus callosum, when transmitted a s an autosomal dominant trait, is clinically characterized by a relati vely milder phenotype than that occurring when inheritance is either a utosomal or X-linked recessive and may be more common than has been th ought. (C) 1997 Wiley-Liss, Inc.