Mk. Kennedy et al., INTERLEUKIN-12 REGULATES THE PROLIFERATION OF TH1, BUT NOT TH2 OR TH0, CLONES, European Journal of Immunology, 24(10), 1994, pp. 2271-2278
Our results indicate that interleukin (IL)-12 is an important costimul
ator of antigen-dependent proliferation of murine Th1 clones. In addit
ion, we demonstrate that IL-10 inhibits splenic antigen-presenting cel
l (APC)-dependent proliferation of Th1 clones, at least in part, via d
own-regulation of APC-derived IL-12. Moreover, the failure of activate
d B cells to provide costimulation via IL-12 accounts for their inabil
ity to support optimal proliferative responses of Th1 clones. We also
show that IL-12 regulates the ability of Th1 clones to respond to IL-4
and enhances their proliferation in response to IL-2, IL-7, or IL-15.
In contrast, Th2 and Th0 clones appear refractory to the effects of I
L-12 on antigen-dependent or growth factor-induced proliferation.