The perception threshold for epidural spinal cord stimulation in chron
ic pain management was analyzed on 3993 testing data obtained from 136
implanted patients. The initial areas of paresthesiae due to stimulat
ion were recorded and reported as the stimulation map according to the
location of electrodes. Measurement of dorsal thickness of the cerebr
ospinal fluid (CSF) layer was obtained from 26 subjects using magnetic
resonance imaging (MRI). The results indicate that the perception thr
eshold is a function of the spinal level of the implanted electrodes,
of the mediolateral position in the spinal canal and the contact separ
ation of electrode. Differences in perception threshold at various ver
tebral levels are mainly due to varying depths of the dorsal CSF layer
. The medially placed electrodes caudal to the mid-cervical levels hav
e a higher perception threshold than more laterally placed ones. The e
lectrodes at high and mid-cervical levels, however, have a smaller per
ception threshold if placed medially. The information obtained from th
is investigation has important implications for the design of a new-ge
neration stimulation system and clinical application to maximize the l
ongevity of the power source.