AN INTRAMOLECULAR ADDITION-ELIMINATION STRATEGY FOR THE SYNTHESIS OF CARBAPENEMS

Authors
ZIEGLER CB CURRAN WV FEIGELSON GB BITHA P FABIO P STROHMEYER T SHORT K LIN YI
Citation
Cb. Ziegler et al., AN INTRAMOLECULAR ADDITION-ELIMINATION STRATEGY FOR THE SYNTHESIS OF CARBAPENEMS, Tetrahedron, 50(42), 1994, pp. 12085-12096
Citations number
50
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
42
Year of publication
1994
Pages
12085 - 12096
Database
ISI
SICI code
0040-4020(1994)50:42<12085:AIASFT>2.0.ZU;2-M
Abstract
The synthesis of 2-[(4-fluorophenylsulfonyl)methyl] carbapenem carboxy late 20 is described. The key step is a base mediated addition-elimina tion ring closure of a iodovinyl sulfone 12.