MEDIAN ARCUATE LIGAMENT SYNDROME - A POSSIBLE CAUSE OF IDIOPATHIC GASTROPARESIS

The median arcuate ligament syndrome (MALS) is characterized by abdomi nal pain, nausea, and vomiting attributed to compression of the celiac axis by a fibrous band (the median arcuate ligament) connecting the d iaphragmatic crura. The pathophysiologic origin of these symptoms is n ot clearly understood. Theories invoking either a neurogenic or vascul ar origin for the clinical features associated with MALS have been pro posed, but objective evidence to support these theories is lacking. We describe the clinical course and gastric myoelectrical features of a patient with postprandial epigastric pain, weight loss, gastroparesis, and gastric dysrhythmias in whom a diagnosis of MALS was established. Surgical decompression of the celiac axis in our patient resulted in resolution of abdominal pain, return to a full diet within 4 weeks wit hout nausea or vomiting, improvement in radionuclide gastric emptying, and restoration of the gastric electrical rhythm to a normal 3 cycle/ min conduction rate. This is the first demonstration of altered gastri c myoelectrical activity in a patient with MALS. The regularization of the gastric electrical rhythm in our patient after surgical decompres sion of the celiac axis would support a neurogenic basis for the sympt oms associated with MALS. MALS should be excluded in patients with idi opathic gastroparesis and unexplained epigastric pain.