AMBIGUITY OF TRANSLATION - A EUKARYOTIC V ERSION

In this review, the results of studies on genetic control of translati on in the yeasts are considered and analyzed. The studies were perform ed on the system of the SUP35(SUP2) and SUP45(SUP1) genes. Based on da ta from genetic analysis, the study of protein synthesis in mutants at these genes, sequencing of both genes, deletion analysis of their fun ctions, and the discovery of homologues of these genes in other eukary otes, it may be assumed that the gene system under study is a specific evolutionarily conservative system for eukaryotes. This system not on ly controls translational fidelity, but also ensures integration of tr anslation with other cellular processes.