EFFECTS OF LANSOPRAZOLE AND OMEPRAZOLE ON 24-HOUR GASTRIC-ACIDITY ANDBASE-LINE ACID OUTPUT IN 9 PATIENTS WITH ZOLLINGER-ELLISON-SYNDROME

Objectives. - This paper aimed at evaluating the comparative efficacy of lansoprazole and omeprazole in reducing gastric acid secretion in p atients suffering from Zollinger-Ellison syndrome. Methods.-Nine patie nts with non-resected gastrinoma(s) and previously well controlled by omeprazole (mean dosage 75 +/- 12.4 (SEM) mg/day; extremes: 20-160 mg/ day) underwent 24-hour intragastric pH-metry, baseline acid output bef ore next dosing and serum gastrin dosages, receiving their usual thera py and thereafter lansoprazole at a weight equivalent posology (mean d osage: 81.6 +/- 12.5 (SEM) mg/day; extremes: 30-165 mg/day). Results. - Lansoprazole maintained intragastric pH and basal acid output at the rapeutic levels, but a discrete reacidification, that deserves confirm ation on a larger group of patients, was observed between the meals. C onclusions. - The possible long-term benefit of this phenomenon, espec ially on gastrinemia and the fundic ECL-cells density and gastric bact erial content, remains to be evaluated.