PRIMED LYMPHOCYTES ARE BOOSTED BY TYPE-II COLLAGEN OF THEIR HOSTS AFTER ADOPTIVE TRANSFER

Citation
A. Dietrich et al., PRIMED LYMPHOCYTES ARE BOOSTED BY TYPE-II COLLAGEN OF THEIR HOSTS AFTER ADOPTIVE TRANSFER, Journal of autoimmunity, 7(5), 1994, pp. 601-609
Citations number
33
Categorie Soggetti
Immunology
Journal title
ISSN journal
08968411
Volume
7
Issue
5
Year of publication
1994
Pages
601 - 609
Database
ISI
SICI code
0896-8411(1994)7:5<601:PLABBT>2.0.ZU;2-7
Abstract
A central question in understanding autoimmunity is whether an endogen ous self-antigen can drive an immune response initially triggered by a foreign one. This possibility is here tested by adoptive transfer, in which T and B cells from mice primed with foreign type II collagen we re transferred into irradiated syngeneic hosts. Previous work with oth er protein antigens has established that primed cells normally respond only if boosted after transfer with antigen. In the present case, and in respect only to that portion of the antibody response able to bind to endogenous type II collagen, that requirement did not hold. This i ndicates that the anti-self component is indeed driven by endogenous a ntigen, which the transferred lymphocytes presumably obtain from their adoptive hosts. The transfers were carried out in C57BL10.A x DBA/1 m ice using donors primed with either chick or bovine collagen, and the non-boosted responses, presumably driven by endogenous antigen, could be followed in a proportion of the recipients for as long as 45 days,