POEMS SYNDROME AND NEPHROPATHY

We describe a patient with POEMS or Crow-Fukase syndrome whose needle renal biopsy specimen showed nephropathy, with findings compatible wit h a mesangiocapillar glomerulopathy. This biopsy showed phenomena of g lomerular mesangiolysis and tubulointerstitial damage with homogeneous tubular casts. The immunofluorescence was positive for kappa light ch ains, apparently in peritubular-linear form. We conclude that the rena l pathology in POEMS syndrome seldom causes symptoms, but it may be mo re frequent histologically. This nephropathy can show aspect s of glom erular (mesangiolysis) and interstitial damage.