Infectious mononucleosis is found worldwide. The clinical manifestatio
ns vary widely. We report a case with impressive swelling of the hard
and soft palate. Inflammation in the region of the efferent ducts of t
he palatinal glands resulted in congestion in the region of the mucino
us salivary glands. The subsequent secretory stasis caused degeneratio
n of the acini and rupture of a salivary retention cyst. The surroundi
ng connective tissue was soaked with mucin, and unspecific chronic gra
nular inflammation was found. Immunohistochemical examination with a m
onoclonal EBV antibody was necessary to show that the exceptional clin
ical picture was due to infectious mononucleosis.