THE VALUE OF MEASURING SERUM TPA LEVELS I N BRONCHOPULMONARY CANCER -A COMPARATIVE-STUDY WITH ACE, CA 19.9 AND NSE LEVELS

This study concerns 45 patients group one suffering from bronchopulmon ary cancer, the diagnosis was obtained by bronchial biopsies or by tra nsparietal puncture using a scanner: there were 35 non-small cell bron chial carcinomas (CNPC) and 10 small cell bronchial cancers (CPC). The control patients (99 patients) were divided up as follows: 44 pleuro- pulmonary infections (group two) and 55 with respiratory failure of va rious causes other than infectious episodes (group three). In group on e the level for TPA was positive in 30 cases (the threshold value was 90 units per litre), 9 for CA 19.9, 7 for A CE and 9 for NSE. The over all sensitivity was thus better for TPA. There was no correlation betw een TPA and type of tumour histology nor between the different markers . Their association did not improve the sensitivity. The NSE however, remained the most sensitive test for the diagnosis of CPC with six pos itive tests out of ten. In the control population, the specitivity of TPA (66%) was less than that of ACE (100%) or of CA 19.9 (94%) and the false positives were significantly more numerous in group two: 21 pat ients had a positive test compared to only 12 in group three.Finally w e noticed an increase in the level of TPA contrary to other markers, a s a function of the extent of the disease from the carcinoma (CNPC uni que). The TPA is thus the most sensitive and it turns out to be better reflector to the extent of the tumour disease than either ACE, CA 19. 9 or NSE but this applies uniquely to non-small cell carcinoma.