INTERNAL-FIXATION WITH BIODEGRADABLE PLATE AND SCREWS IN DOGS

Citation
Wb. Lehman et al., INTERNAL-FIXATION WITH BIODEGRADABLE PLATE AND SCREWS IN DOGS, Journal of pediatric orthopedics. Part B, 3(2), 1994, pp. 190-193
Citations number
NO
Categorie Soggetti
Orthopedics,Pediatrics
ISSN journal
1060152X
Volume
3
Issue
2
Year of publication
1994
Pages
190 - 193
Database
ISI
SICI code
1060-152X(1994)3:2<190:IWBPAS>2.0.ZU;2-3
Abstract
In vivo and in vitro studies were performed over the past 6 years to e valuate the short- and long-term biocompatibility, absorbability, stre ngth, and efficacy of polylactic acid (PLA) as a suitable material for an internal fixation system of bone, consisting of a plate and screws . The study was conducted on 30 dogs that underwent osteotomy of the r adius and three dogs that underwent osteotomy of the femur. Bone fragm ents were fixed by the PLA plate and screws. In all specimens, the ost eotomy healed in the usual length of time. The dogs were killed after 12 weeks to 4 years. At the time of death, specimens were obtained for mechanical testing and histological analysis. It appears that PLA is biocompatible, is of adequate strength, and has a suitable absorption pattern in the canine model in which it was tested. PLA did not interf ere with the process of bone healing and was completely absorbed 4 yea rs after implantation.