SESQUITERPENE PYRIDINE ALKALOIDS FROM MAYTENUS-CHUCHUHUASCA

Structural elucidations of seven novel sesquiterpene pyridine alkaloid s, chuchuhuanines E-I (1), E-II (2), E-III (3), E-IV (4), E-V (5), W-I (6) and 4-deoxyeuonymine (7), which were isolated along with seven kn own alkaloids from root barks of Maytenus chuchuhuasca Raymond-Hamet e t Colas (Celastraceae), are presented. Their structures with a novel d ihydro-beta-agarofuran type sesquiterpene core, linking several ester moieties and including a fifteen or a sixteen membered macrocyclic die ster ring system, were elucidated by mainly spectroscopic methods.