APLASIA AFTER DONOR LYMPHOCYTE INFUSION (DLI) FOR CML IN RELAPSE AFTER SEX-MISMATCHED BMT - RECOVERY OF DONOR-TYPE HEMATOPOIESIS PREDICTED BY NONISOTOPIC IN-SITU HYBRIDIZATION (ISH)

Authors
GARICOCHEA B VANRHEE F SPENCER A CHASE A LIN F CROSS NCP GOLDMAN JM
Citation
B. Garicochea et al., APLASIA AFTER DONOR LYMPHOCYTE INFUSION (DLI) FOR CML IN RELAPSE AFTER SEX-MISMATCHED BMT - RECOVERY OF DONOR-TYPE HEMATOPOIESIS PREDICTED BY NONISOTOPIC IN-SITU HYBRIDIZATION (ISH), British Journal of Haematology, 88(2), 1994, pp. 400-402
Citations number
8
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
88
Issue
2
Year of publication
1994
Pages
400 - 402
Database
ISI
SICI code
0007-1048(1994)88:2<400:AADLI(>2.0.ZU;2-P
Abstract
We report a patient with CML in relapse after a sex-mismatch bone marr ow transplant who was treated with donor lymphocyte infusions and deve loped severe marrow aplasia 3 months later. As cytogenetic analysis at this point was not possible because of the very low number of marrow cells available, we used in situ hybridization (ISH) for sex chromosom es and the BCR/ABL gene together with quantitative PCR to monitor the patient's response. The results suggest that recovering haemopoiesis w as derived from donor cells and contributed to the decision not to tra nsfuse donor marrow cells on a second occasion.