CYTOSINE-ARABINOSIDE (ARA-C) PLUS ALPHA-INTERFERON (ALPHA-IFN) DETERMINE PROLONGED COMPLETE REMISSIONS IN PATIENTS WITH AGGRESSIVE NON-HODGKINS-LYMPHOMA PARTIALLY RESPONSIVE TO FIRST-LINE DOXORUBICIN-CONTAINING REGIMENS

Authors
PALMIERI G MORABITO A REA A CARAGLIA M TAGLIAFERRI P BIANCO AR
Citation
G. Palmieri et al., CYTOSINE-ARABINOSIDE (ARA-C) PLUS ALPHA-INTERFERON (ALPHA-IFN) DETERMINE PROLONGED COMPLETE REMISSIONS IN PATIENTS WITH AGGRESSIVE NON-HODGKINS-LYMPHOMA PARTIALLY RESPONSIVE TO FIRST-LINE DOXORUBICIN-CONTAINING REGIMENS, British Journal of Haematology, 88(2), 1994, pp. 421-423
Citations number
10
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
88
Issue
2
Year of publication
1994
Pages
421 - 423
Database
ISI
SICI code
0007-1048(1994)88:2<421:C(PA(D>2.0.ZU;2-A
Abstract
Ten patients with aggressive NHL who failed to achieve a complete remi ssion with first-line chemotherapy were treated with Ara-C and alpha I FN. Ara-C was administered subcutaneously at 100 mg on day 1, 150 mg o n day 2 and 200 mg on days 3, 4 and 5 of a 28 d cycle; alpha IFN was g iven at 3 million International Units three times a week and continued for 2 years in CR patients. Six CR were attained with a median durati on of 36+ months. Toxicity was mild. A new approach to second-line the rapy for aggressive NHL is proposed.