GENOMIC CROSS-TALK BETWEEN THE ESTROGEN-RECEPTOR AND GROWTH-FACTOR REGULATORY PATHWAYS IN ESTROGEN TARGET TISSUES

Authors
CHALBOS D PHILIPS A ROCHEFORT H
Citation
D. Chalbos et al., GENOMIC CROSS-TALK BETWEEN THE ESTROGEN-RECEPTOR AND GROWTH-FACTOR REGULATORY PATHWAYS IN ESTROGEN TARGET TISSUES, Seminars in cancer biology, 5(5), 1994, pp. 361-368
Citations number
50
Categorie Soggetti
Oncology
Journal title
Seminars in cancer biology → ACNP
ISSN journal
1044579X
Volume
5
Issue
5
Year of publication
1994
Pages
361 - 368
Database
ISI
SICI code
1044-579X(1994)5:5<361:GCBTEA>2.0.ZU;2-F
Abstract
Cell proliferation and differentiation are modulated by both estrogens and growth factors. Even though these two kinds of effectors interact with receptors localized in different compartments of the cell, their nuclear end points are often on the same genes. We review here the fi rst evidence for transcriptional interference between these two regula tory pathways which might be essential in understanding the control of cell proliferation and invasion in human estrogen-responsive cancers.