BCL-2 OVEREXPRESSION ABOLISHES EARLY CALCIUM WAVING PRECEDING APOPTOSIS IN NIH-3T3 MURINE FIBROBLASTS

Authors
MAGNELLI L CINELLI M TURCHETTI A CHIARUGI VP
Citation
L. Magnelli et al., BCL-2 OVEREXPRESSION ABOLISHES EARLY CALCIUM WAVING PRECEDING APOPTOSIS IN NIH-3T3 MURINE FIBROBLASTS, Biochemical and biophysical research communications, 204(1), 1994, pp. 84-90
Citations number
19
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
204
Issue
1
Year of publication
1994
Pages
84 - 90
Database
ISI
SICI code
0006-291X(1994)204:1<84:BOAECW>2.0.ZU;2-L
Abstract
Overexpression of the apoptosis protection gene bcl-2 abolished the ea rliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e ., the abrupt cytoplasmic free calcium drop. This phenomenon, also obs erved in a myeloid cell line, led us to propose this ionic waving as a n early apoptotic signal. Its abolition by bcl-2 overexpression sugges ts that this gene plays a role also on early events ''priming'' apopto sis. (C) Academic Press, Inc.