INHIBITION OF IN VITO TRANSLATION OF INFLUENZA-VIRUS NP PROTEIN MESSENGER-RNA BY ANTISENSE OLIGONUCLEOTIDE DERIVATIVES

The inhibitory activity of an oligonucleotide complementary to the mRN A 5' terminus and its derivatives containing aromatical 2-chloroethyla mine, cholesterol porphyrin, and phenazinium residues at the 5' termin us was evaluated in a cell-free translation system from rabbit reticul ocytes. It was shown that introduction of alkylating, cholesterol, or phenazinium group into the antisense oligonucleotide increases its inh ibitory activity.